Induced Pluripotent Stem Cells
Reprogramming Factors
Recently, pioneering work has revealed that terminally
differentiated somatic cells can be reprogrammed to generate
induced pluripotent stem (iPS) cells via overexpression of a
defined set of transcription factors.
These iPS cells are morphologically and phenotypically similar
to embryonic stem (ES) cells and offer exciting possibilities in
stem cell research and regenerative medicine.
InvivoGen offer an innovative range of tools for the study of
and generation of iPS cells:-
Native Reprogramming Factors Genes (iPSC genes)
InvivoGen offers native reprogramming factor genes provided in
expression plasmids (Oct4, Sox2,
Klf4, and c-Myc (OSKM) , NANOG
and LIN28).
Reprogramming factors genes allow the production of recombinant
cell-penetrating reprogramming factors. These genes are also
HA-tagged for easy detection or purification.
To facilitate the generation of iPS cells, InvivoGen has
developed LENTI-Smart™ OSKM for the production of lentiviral
vectors expressing the human or murine OSKM reprogramming genes.
Reprogramming Enhancers Oct4,
Sox2, Klf4, and
c-Myc (OSKM).
InvivoGen offers a selection of small molecules that have
recently been reported to either enhance reprogramming efficiencies
or substitute for specific reprogramming factors.
5-Aza-cytidine
Bix-01294
PD0325901
SB431542
Valproic Acid
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reprogramming factors