Target Identification & Validation

How we can support the drug development pipeline

Target identification and validation are bottlenecks in drug development. Accurate and reliable automated methods need to be employed, supported by comprehensive bioinformatics to analyse all the data generated in the search for the next drug or disease target.

Source BioScience provides all aspects of DNA and RNA analysis, from whole genome sequencing and transcriptome analysis to targeted measurement of individual genetic variation and miRNA profiling. Together with experienced staff who worked on the human genome project, Source BioScience offers the expertise and bioinformatics capabilities to identify potential targets for new therapeutics and potential diagnostic indicators for disease. Using these capabilities, we can provide comprehensive data to support development studies, saving our clients time and money.

Target validation in tissue

Source BioScience understands the importance of validating potential drug targets in cells, so we have coupled genomic studies with validation of protein expression in tissue.

Using semi-quantitative immunohistochemistry (IHC) and fluorescence in-situ hybridisation (FISH), supported by expert pathologist review, we provide a comprehensive package of data to support target validation studies.

We can offer support and assay design for protein and novel target expression in a range of normal and diseased tissue, including :

  • IHC and novel marker assay development & co-localisation studies
  • ISH, molecular cytogenetics (FISH), and conventional G-banding cytogenetics
  • Tissue microarray development
  • Virtual Microscopy with web browser access
  • Internal expertise in phosphorylated marker assay development