RNA interference (RNAi) has become the tool of choice for studying gene function by sequence-specific gene silencing in the presence of double stranded RNA (dsRNA) in the cell.
Source BioScience and Sigma-Aldrich have formed a cooperation to provide leading RNAi tools for gene silencing including siRNA and shRNA resources.
MISSION®shRNA tools were developed within the efforts of The RNAi Consortium (TRC) to generate genome-scale libraries based on a vector that allows transfection and transduction of a broad range of target cells.
Pre-designed MISSION®siRNAs were established in an exclusive partnership with Rosetta Inpharmatics, using a proprietary and highly innovative design algorithm ensuring a most effective and specific knockdown of the targeted gene.
short/long term gene silencing
long term gene silencing for cells which are difficult to transfect
RNA duplex molecule
short term gene silencing
Gene Silencing by RNAi - The Basics