RNA Interference
RNAi - Gene Function Revealed by RNA
Interference
RNA interference (RNAi) has become the tool of choice for
studying gene function by sequence-specific gene silencing in the
presence of double stranded RNA (dsRNA) in the cell.
Source BioScience LifeSciences and Sigma-Aldrich have formed a
cooperation to provide leading RNAi tools for gene silencing
including siRNA and shRNA resources.
MISSION®shRNA tools were developed within the efforts of The
RNAi Consortium (TRC) to generate genome-scale libraries based
on a vector that allows transfection and transduction of a broad
range of target cells.
Pre-designed MISSION®siRNAs were established in an exclusive
partnership with Rosetta Inpharmatics, using a proprietary and
highly innovative design algorithm ensuring a most effective and
specific knockdown of the targeted gene.
Available Products
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Category
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Type
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Applications
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shRNA
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plasmid
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short/long term gene silencing
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lentiviral particle
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long term gene silencing for cells which are difficult to
transfect
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siRNA
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RNA duplex molecule
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short term gene silencing
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Gene Silencing by RNAi - The
Basics