siRNA
Pre-designed MISSION™ siRNAs for specific knockdown of
human, rat and mouse genes
Source BioScience LifeSciences, in cooperation with
Sigma-Aldrich, offers the best performing siRNA resources to suit
your specific needs for gene silencing. The MISSION™ line of siRNA
was created using the Rosetta siRNA Design
Algorithm. Key features of this algorithm include proprietary
design rules for reduced off-target effects and for improved
knockdown also for low abundant messages (< 10 copies /
cell).
Benefits of MISSION™ siRNA
- Easy - fast and convenient handling, easily titrated,
transfected at high efficiency
- Comprehensive - selection of up to ten siRNA molecules per
target gene matching to different regions in the transcript
- Efficient - increased target specificity and potent knockdown
of low abundance messages due to optimisation rules of the Rosetta
Algorithm
- Economical - guaranteed gene silencing
- Quality - high quality siRNA produced at ISO 9000:2001
certified sites
MISSION™ siRNA Product Overview
Source BioScience LifeSciences offer comprehensive collections
of MISSION siRNAs targeting 28172 human, 27493 mouse or 17647 rat
genes.
A gene-based search for available siRNAs results in a display of
up to 10 different suggestions per gene, ranked for knockdown
efficiency as modelled by the Rosetta algorithm. Annotation of the
approximate target position gives you a choice to tailor your
experiment to particular regions in the transcript of interest.
We guarantee that 2 out of 3 siRNA duplexes selected from this
panel will achieve knockdown efficiencies of greater than or equal
to 75%. With selecting 3 siRNAs from the panel, you will therefore
make sure to obtain a successful experimental result.
Depending on the scope of your experiments, you can choose one
of 3 different synthesis scales (2 OD correspond to ~ 10 nmol). It
is recommended to start a titration experiment using siRNA
concentrations from 5nM up to 30nM.
The expected delivery time will around 5 working days.