C. elegans ORF-RNAi library | Source BioScience

This ORF-based RNAi library is ideal for either high-throughput screening or individual knockdown experiments.

The ORFeome-RNAi v1.1 library contains 11,511 RNAi clones, which targets 10,953; 485 of these genes are targeted by 2 or more constructs. The library therefore covers the potential knockdown of 55% of the 19,920 unique protein-coding genes predicted in "worm sequence" 112.

Interestingly, there are ~1,700 unique genes not previously targeted by existing RNAi feeding libraries (an additional ~9% of the worm genome). Therefore, in conjunction with our exciting RNAi feeding library the overall predicted coverage of worm genes is ~86%.


Source BioScience offers individual clone(s) for research purposes only. We can also make subsets of your chosen clones from the collection. Please contact us to discuss your requirements.


Rual JF, Ceron J, Koreth J, Hao T, Nicot AS, Hirozane-Kishikawa T, Vandenhaute J, Orkin SH, Hill DE, van den Heuvel S, Vidal M. "Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library". Genome Res. 2004 Oct;14(10B):2162-8. Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.