Genomic Services Citations

Sundaramoorthy. S., Vázquez-Novelle. M., Lekomtsev. S., Howell. M., Petronczki. M. (2014). Functional genomics identifies a requirement of pre-mRNA splicing factors for sister chromatid cohesion. EMBO J. 33(22):2623-42.

McNeill. A., Magalhaes. J., Shen. C., Chau. K., Hughes. D., Mehta. A., Foltynie. T., Cooper. J., Abramov. A., Gegg. M., Schapira. A. (2014). Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. Brain. 137(5):1481-95.

Walsh. C., Bolger. J., Byrne. C., Cocchiglia. S., Hao. Y., Fagan. A., Qin. L., Cahalin. A. et al. (2014). Global gene repression by the steroid receptor coactivator SRC-1 promotes oncogenesis. Cancer Res. 74(9):2533-44.

Schuh. C., Wimmer. I., Hametner. S., Haider. L., Van Dam. A., Liblau. R. et al. (2014). Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models. Acta Neuropathol. 128(2):247-66.

Lindner. J., Kayo. H., Hedlund. S., Fukuda. Y., Fukao. T., Nielsen. P. (2014). Cutting edge: The transcription factor Bob1 counteracts B cell activation and regulates miR-146a in B cells. J. Immunol. 192(10):4483-6.

Sergeant. M., Constantinidou. C., Cogan. T., Bedford. M., Penn. C., Pallen. M. (2014). Extensive microbial and functional diversity within the chicken cecal microbiome. PLoS ONE. 9(3):e91941.

Wain. L., Odenthal-Hesse. L., Abujaber. R., Sayers. I., Beardsmore. C., Gaillard. E., Chappell. E. et al. (2014). Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma. PLoS ONE. 9(1):e84192.

Jowsey. P., Blain. P. (2014). Whole genome expression analysis in primary bronchial epithelial cells after exposure to sulphur mustard. Toxicol. Lett. 230(3):393-401.

Homrich. M., Wobst. H., Laurini. C., Sabrowski. J., Schmitz. B., Diestel. S. (2014). Cytoplasmic domain of NCAM140 interacts with ubiquitin-fold modifier-conjugating enzyme-1 (Ufc1). Exp. Cell Res. 324(2):192-9.

Creamer. E., Shore. A., Deasy. E., Galvin. S., Dolan. A., Walley. N., McHugh. S., Fitzgerald-Hughes. D., Sullivan. D., Cunney. R., Coleman. D., Humphreys. H. (2014). Air and surface contamination patterns of meticillin-resistant Staphylococcus aureus on eight acute hospital wards. J. Hosp. Infect. 86(3):201-8.

Ehmke. M., Luthe. K., Schnabel. R., Döring. F. (2014). S-Adenosyl methionine synthetase 1 limits fat storage in Caenorhabditis elegans. Genes Nutr. 9(2):386.

Schmid. G. Kässner. F., Uhlig. H., Körner. A., Kratzsch. J., Händel. N., Zepp. F., Kowalzik. F., Laner. A., Starke. et al. (2014). Sirolimus treatment of severe PTEN hamartoma tumor syndrome: case report and in vitro studies. Pediatr. Res. 75(4):527-34.

Lenahan. M., Sheridan. Á., Morris. D., Duffy. G., Fanning. S., Burgess. C. (2014). Transcriptomic analysis of triclosan-susceptible and -tolerant Escherichia coli O157:H19 in response to triclosan exposure. Microb. Drug Resist. 20(2):91-103.

Jenkins. S., Pickard. M., Khong. M., Smith. H., Mann. C., Emes. R., Chari. D. (2014). Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy. ACS Chem Neurosci. 5(1):51-63.

Trent. S., Fry. J., Ojarikre. O., Davies. W. (2014). Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder. Mol Autism. 5(1):21.

Johnson. W., Ong. K., Elks. C., Wareham. N., Wong. A., Muniz-Terrera. G., Hardy. R. et al. (2014). Modification of genetic influences on adiposity between 36 and 63 years of age by physical activity and smoking in the 1946 British Birth Cohort Study. Nutr Diabetes. 4:e136.

Moreton. J., Dunham. S., Emes. R. (2014). A consensus approach to vertebrate de novo transcriptome assembly from RNA-seq data: assembly of the duck (Anas platyrhynchos) transcriptome. Front Genet. 5:190.

Condell. O., Power. K., Händler. K., Finn. S., Sheridan. A., Sergeant. K., Renaut. J., Burgess. C. et al. (2014). Comparative analysis of Salmonella susceptibility and tolerance to the biocide chlorhexidine identifies a complex cellular defense network. Front Microbiol. 5:373.

Regan. C., Yon.  L., Hossain. M., Elsheikha. H. (2014). Prevalence of Entamoeba species in captive primates in zoological gardens in the UK. PeerJ. 2:e492.

Casey. A., Fox. E., Schmitz-Esser. S., Coffey. A., McAuliffe. O., Jordan. K. (2014). Transcriptome analysis of Listeria monocytogenes exposed to biocide stress reveals a multi-system response involving cell wall synthesis, sugar uptake, and motility. Front Microbiol. 5:68.

Agyemang. C., Beune. E., Meeks. K., Owusu-Dabo. E., Agyei-Baffour. P., Aikins. A., Dodoo. F., Smeeth. L., Addo. et al. (2014).  Rationale and cross-sectional study design of the Research on Obesity and type 2 Diabetes among African Migrants: the RODAM study. BMJ Open. 4(3):e004877.

Fischer. A., Niklowitz. P., Menke. T., Döring. F. (2014). Promotion of growth by Coenzyme Q10 is linked to gene expression in C. elegans. Biochemical and Biophysical Research Communications. 452:920–927.

Helwak. A., Kudla. G., Dudnakova. T., Tollervey. D. (2013). Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding. Cell.153(3):654-65.

Tuck. A., Tollervey. D. (2013). A transcriptome-wide atlas of RNP composition reveals diverse classes of mRNAs and lncRNAs. Cell. 154(5):996-1009.

Hametner. S., Wimmer. I., Haider. L., Pfeifenbring. S., Brück. W., Lassmann. H. (2013). Iron and neurodegeneration in the multiple sclerosis brain. Ann. Neurol. 74(6):848-61.

Fischer. M., Wimmer. I., Höftberger. R., Gerlach. S., Haider. L., Zrzavy. T., Hametner. S., Mahad. D., Binder. C. et al. (2013). Disease-specific molecular events in cortical multiple sclerosis lesions. Brain. 136(6):1799-815.

Gioti. A., Stajich. J., Johannesson. H. (2013). Neurospora and the dead-end hypothesis: genomic consequences of selfing in the model genus. Evolution. 67(12):3600-16.

Davidson. R., Jupp. O., de Ferrars. R., Kay. C., Culley. K., Norton. R., Driscoll. C., Vincent. T. et al. (2013). Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo. Arthritis Rheum. 65(12):3130-40.

McNally. A., Alhashash. F., Collins. M., Alqasim. A., Paszckiewicz. K., Weston. V., Diggle. M. (2013). Genomic analysis of extra-intestinal pathogenic Escherichia coli urosepsis. Clin. Microbiol. Infect. 19(8):E328-34.

McCaughey. G., Gilpin. D., Schneiders. T., Hoffman. L., McKevitt. M., Elborn. J., Tunney. M. (2013). Fosfomycin and tobramycin in combination downregulate nitrate reductase genes narG and narH, resulting in increased activity against Pseudomonas aeruginosa under anaerobic conditions Antimicrob. Agents Chemother. 57(11):5406-14.

Carter. J., Baker. S., Pink. R., Carter. D., Collins. A., Tomlin. J., Gibbs. M., Breuker. C. (2013). Unscrambling butterfly oogenesis. BMC Genomics. 14:283.

Miersch. C., Döring. F. (2013). Sex differences in body composition, fat storage, and gene expression profile in Caenorhabditis elegans in response to dietary restriction. Physiol. Genomics. 45(13):539-51.

Samson. R., Xu. Y., Gadelha. C., Stone. T., Faqiri. J., Li. D., Qin. N., Pu. F. et al. (2013). Specificity and function of archaeal DNA replication initiator proteins. Cell Rep. 3(2):485-96.

Nojima. T., Dienstbier. M., Murphy. S., Proudfoot. N., Dye. M. (2013). Definition of RNA polymerase II CoTC terminator elements in the human genome. Cell Rep. 3(4):1080-92.

Linka. Y., Ginzel. S., Krüger. M., Novosel. A., Gombert. M., Kremmer. E., Harbott. J., Thiele. R. et al. (2013). The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods. Blood Cancer J. 3:e151.

Rettino. A., Clarke. N. (2013). Genome-wide Identification of IRF1 Binding Sites Reveals ExtensiveOccupancy at Cell Death Associated Genes. J Carcinog Mutagen. doi:10.4172/2157-2518.S6-009.

Liu. J., Almarri. M., Gaffney. D., Mells. G., Jostins. L., Cordell. H., Ducker. S., Day. D. et al. (2012). Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. Nat. Genet. 44(10):1137-41.

Sun. Y., Corcoran. P., Menkis. A., Whittle. C., Andersson. S., Johannesson. H. (2012). Large-scale introgression shapes the evolution of the mating-type chromosomes of the filamentous ascomycete Neurospora tetrasperma. PLoS Genet. 8(7):e1002820.

Koerner. M., Pauler. F., Hudson. Q., Santoro. F., Sawicka. A., Guenzl. P., Stricker. S., Schichl. (2012). A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter. PLoS Genet. 8(3):e1002540.

McCartan. D., Bolger. J., Fagan. A., Byrne. C., Hao. Y., Qin. L., McIlroy. M. (2012). Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer. Cancer Res. 72(1):220-9.

Rhodes. J., Lott. M., Russell. S., Moulton. V., Sanderson. J., Wormstone. I., Broadway. D. (2012). Activation of the innate immune response and interferon signalling in myotonic dystrophy type 1 and type 2 cataracts. Hum. Mol. Genet. 21(4):852-62.

Webb. T., Parfitt. D., Gardner. J., Martinez. A., Bevilacqua. D., Davidson. A., Zito. I. et al. (2012). Deep intronic mutation in OFD1, identified by targeted genomic next-generation sequencing, causes a severe form of X-linked retinitis pigmentosa (RP23). Hum. Mol. Genet. 21(16):3647-54.

Wojtas. M., Mogni. M., Millet. O., Bell. S., Abrescia. N. (2012). Structural and functional analyses of the interaction of archaeal RNA polymerase with DNA. Nucleic Acids Res. 40(19):9941-52.

Rogers. H., Kilday. J., Mayne. C., Ward. J., Adamowicz-Brice. M., Schwalbe. E., Clifford. S., Coyle. B., Grundy. R.(2012). Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death. Acta Neuropathol. 123(5):711-25.

Reyes-Sandoval. A., Rollier. C., Milicic. A., Bauza. K., Cottingham. M., Tang. C., Dicks. M. et al. (2012). Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity. Mol. Ther. 20(8):1633-47.

Leeb. M., Walker. R., Mansfield. B., Nichols. J., Smith. A., Wutz. A. (2012). Germline potential of parthenogenetic haploid mouse embryonic stem cells. Development. 139(18):3301-5.

Stoute. A., Varenko. V., King. G., Scott. R., Kurup. S. (2012). Parental genome imbalance in Brassica oleracea causes asymmetric triploid block. Plant J. 71(3):503-16.

Elks. C., Loos. R., Hardy. R., Wills. A., Wong. A., Wareham. N., Kuh. D., Ong. K. (2012). Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study. Am. J. Clin. Nutr. 95(5):1150-6.

Herbert. J., Ban. M., Brown. G., Harris. T., Ogilvie. A., Uher. R., Craig. T. (2012). Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women. Br J Psychiatry. 201(4):313-9.

Shore. A., Brennan. O., Deasy. E., Rossney. A., Kinnevey. P., Ehricht. R., Monecke. S., Coleman. D. (2012). DNA microarray profiling of a diverse collection of nosocomial methicillin-resistant Staphylococcus aureus isolates assigns the majority to the correct sequence type and staphylococcal cassette chromosome mec (SCCmec) type and results in the subsequent identification and characterization of novel SCCmec-SCCM1 composite islands. Antimicrob. Agents Chemother. 56(10):5340-55.

Dalmasso. M., Aubert. J., Briard-Bion. V., Chuat. V., Deutsch. S., Even. S., Falentin. H. (2012). A temporal-omic study of Propionibacterium freudenreichii CIRM-BIA1 adaptation strategies in conditions mimicking cheese ripening in the cold. PLoS ONE. 7(1):e29083.

Miersch. C., Döring. F. (2012). Sex differences in carbohydrate metabolism are linked to gene expression in Caenorhabditis elegans. PLoS ONE. 7(9):e44748.

Larsen. M., Cosentino. S., Rasmussen. S., Friis.  C., Hasman. H., Marvig. R., Jelsbak. L. et al. (2012). Multilocus sequence typing of total-genome-sequenced bacteria. J. Clin. Microbiol. 50(4):1355-61.

Strube. C., Buschbaum. S., Schnieder. T. (2012). Genes of the bovine lungworm Dictyocaulus viviparus associated with transition from pasture to parasitism. Infect. Genet. Evol. 12(6):1178-88.

Hartling. H., Gaardbo. J., Ronit. A., Knudsen. L., Ullum. H., Vainer. B., Clausen. M. (2012). CD4⁺ and CD8⁺ regulatory T cells (Tregs) are elevated and display an active phenotype in patients with chronic HCV mono-infection and HIV/HCV co-infection. Scand. J. Immunol. 76(3):294-305.

Lancaster. T., Linden. D., Heerey. E. (2012). COMT val158met predicts reward responsiveness in humans. Genes Brain Behav. 11(8):986-92.

Michaelis. M., Barth. S., Breitling. R., Bruch. J., Steinberger. D., Rothweiler. F. (2012). Selection of a highly invasive neuroblastoma cell population through long-term human cytomegalovirus infection. Oncogenesis. 1:e10.

Lord. J., Turton. J., Medway. C., Shi. H., Brown. K., Lowe. J., Mann. D., Pickering-Brown. S., Kalsheker. N., Passmore. P., Morgan. K., Alzheimer’s Research UK(ARUK) Consortium. (2012). Next generation sequencing of CLU, PICALM and CR1: pitfalls and potential solutions. Int J Mol Epidemiol Genet. 3(4):262-75.

Wagner. A., Ernst. I., Birringer. M., Sancak. O., Barella. L., Rimbach. G. (2012). A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells. Oxid Med Cell Longev. 835970.

Mells. G., Floyd. J., Morley. K., Cordell. H., Franklin. C., Shin. S., Heneghan. M., Neuberger. et al. (2011). Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nat. Genet. 43(4):329-32.

Leitao. B., Jones. M., Brosens. J. (2011). The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death. FASEB J. 25(10):3416-25.

Colombari. D., Colombari. E., Freiria-Oliveira. A., Antunes. V., Yao. S., Hindmarch. C., Ferguson. A., Fry. M. et al. (2011).  Switching control of sympathetic activity from forebrain to hindbrain in chronic dehydration. J. Physiol. (Lond.). 589(18):4457-71.

Shore. A., Rossney. A., Brennan. O., Kinnevey. P., Humphreys. H., Sullivan. D., Goering. R. et al. (2011). Characterization of a novel arginine catabolic mobile element (ACME) and staphylococcal chromosomal cassette mec composite island with significant homology to Staphylococcus epidermidis ACME type II in methicillin-resistant Staphylococcus aureus genotype ST22-MRSA-IV. Antimicrob. Agents Chemother. 55(5):1896-905.

Whittle. C., Johannesson. H. (2011). Evidence of the accumulation of allele-specific non-synonymous substitutions in the young region of recombination suppression within the mating-type chromosomes of Neurospora tetrasperma. Heredity (Edinb). 107(4):305-14.

Gaysina. D., Pierce. M., Richards. M., Hotopf. M., Kuh. D., Hardy. R. (2011). Association between adolescent emotional problems and metabolic syndrome: the modifying effect of C-reactive protein gene (CRP) polymorphisms. Brain Behav. Immun. 25(4):750-8.

Bennedsen. M., Stuer-Lauridsen. B., Danielsen. M., Johansen. E. (2011). Screening for antimicrobial resistance genes and virulence factors via genome sequencing. Appl. Environ. Microbiol. 77(8):2785-7.

Wang. M., Trim. C., Gullick. W. (2011). Localisation of Neuregulin 1-β3 to different sub-nuclear structures alters gene expression. Exp. Cell Res. 317(4):423-32.

Hindmarch. C., Fry. M., Smith. P., Yao. S., Hazell. G., Lolait. S., Paton. J., Ferguson. A., Murphy. D. (2011). The transcriptome of the medullary area postrema: the thirsty rat, the hungry rat and the hypertensive rat. Exp. Physiol. 96(5):495-504.

Lee. P., Delaney. P., Keogh. J., Sleeman. D., Shorten. G. (2011). Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity. Clin J Pain. 27(2):93-101.

Patel. A., Rees. S., Kelly. M., Bain. S., Barnett. A., Thalitaya. D., Prasher. V. (2011). Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome. Neurosci. Lett. 487(2):144-8.

Khan. N., Rawlings. B., Caffrey. P. (2011). A labile point in mutant amphotericin polyketide synthases. Biotechnol. Lett. 33(6):1121-6.

Hickey. O., Nugent. N., Burke. S., Hafeez. P., Mudrakouski. A., Shorten. G. (2011). Persistent pain after mastectomy with reconstruction. J Clin Anesth. 23(6):482-8.

Whittle. C., Sun. Y., Johannesson. H. (2011). Degeneration in codon usage within the region of suppressed recombination in the mating-type chromosomes of Neurospora tetrasperma. Eukaryotic Cell. 10(4):594-603.

Hardy. R., Wills. A., Wong. A., Elks. C., Wareham. N., Loos. R., Kuh. D., Ong. K. (2010). Life course variations in the associations between FTO and MC4R gene variants and body size. Hum. Mol. Genet. 19(3):545-52.

Pallett. D., Ho. T., Cooper. I., Wang. H. (2010). Detection of Cereal yellow dwarf virus using small interfering RNAs and enhanced infection rate with Cocksfoot streak virus in wild cocksfoot grass (Dactylis glomerata). J. Virol. Methods. 168: 223-7.