Affymetrix GeneChip® Human Mapping Arrays

Description

• The GeneChip ® Mapping arrays from Affymetrix enable genotyping of 10,000 to 1,000,000 single nucleotide polymorphisms (SNPs) on single or paired microarrays.
• SNPs were identified and chosen from the SNP Consortium database. SNPs may occur in sequences where they functionally affect a gene or they may be in apparently non-functional sequences. In either case SNPs can be used as bi-allelic genetic markers for the localisation of genes underlying disease. The result can be a highly informative genome-wide linkage or associated map that can then be used to test linkage or association to a phenotype.

 

Application

In partnership with Source BioScience LifeSciences, GeneChip® assays can genotype 10,000, 50,000, 250,000, 500,000 or 1 million SNPs in a single DNA hybridisation. This platform together with the unique personalised expertise of Source BioScience LifeSciences means that you can save time, increase throughput of SNP genotyping on a previously unprecedented genome-wide scale, obtain the most power in linkage and assocation genotyping from your families and populations and reduce your costs. These GeneChips have also been shown to be excellent tools in determining loss of heterozygosity and chromosomal copy number variation.

Why choose this product:

• Large numbers of SNPs with high percentage calls and high call reproducibility
• Maximises linkage across the genome in your families, able to detect associations in populations
• GeneChip data also allows identification of chromosomal copy number variation (CNV) on a genome-wide scale
• Only 250ng of each genomic DNA required per GeneChip®
• Fully automated genotype calling

 

Use Source BioScience LifeSciences because:

• Fast turnaround time of the experiments to meet your deadlines.
• Long-standing experience of Affymetrix arrays and technology with our well respected Affymetrix quantitative gene expression microarrays.
• Optimised protocols for high-throughput processing meaning your experiments go faster and are cheaper.
• Ten years experience of genetic studies and genetic approaches to finding disease genes through HGMP RC Linkage Hotel.

process outline (pdf)

Example project with pricing

Contact

E-mail: Genotyping Team