They can affect translation and transcription. In some circumstances they lead to profound disease whereas elsewhere will have no obvious effect. SNPs have also been used in pharmacogenomic experiments to predict why some individuals respond better to certain therapeutics.
The special virtues of SNPs for genetic analysis are their ease of discovery and assay, and their ease of analysis. Their high density in the human genome and their effects, in some cases, on transcription and translation make SNPs valuable for association studies.
The TaqMan® platform is suitable for projects of 10s of SNPs and 1000s of Samples. For higher throughput projects customers should consider SNPlex
If you would like more information please contact us