Neurodegenerative disease research

Understanding the mechanisms behind neurodegenerative disease will help in the treatment of diseases such as Alzheimer’s, Parkinson’s and ALS.

Your partner in Neurodegenerative disease research


Alzheimer's

TDP-43/TARDBP: Research has found that TDP-43 amplifies memory loss and hippocampal atrophy in Alzheimer's disease and correlates strongly with cognitive impairment during life. TDP-43 (10782-2-AP) has been cited in 626 publications.

TDP-43 IF

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Parkinson's

ATG5, also named APG5L and ASP, belongs to the ATG5 family. It is required for autophagy and plays an important role in the apoptotic process, possibly within the modified cytoskeleton. Accumulating evidence indicates that autophagy is involved in alpha-synuclein degradation, which is key to the pathology of Parkinsons disease. ATG5 (10181-2-AP) has been cited in 11 publications.

ATG5 IF

 

 

 


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ATG5 IHC


ALS

FUS/TLS is involved in ALS and FTD and is believed to play a role in the maintenance of genomic integrity. FUS/TLS is also an RNA-binding protein, and its links to neurodegenerative disease suggests the possibility that altered RNA metabolism or RNA processing may underlie or contribute to neuron degeneration. FUS/TLS (11570-1-AP) has been cited in 22 papers.

FUS/TLS IF

 

 

 

 

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 FUS/TLS IHC

           








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