Mycoplasma Detection and Eradication

Mycoplasma contamination remains a significant problem in the culture of mammalian cells.  In contrast to other microbial contaminants, mycoplasmas do not cause consistent perceptible changes to the cells, but they can have disastrous effects by altering their parameters.

Source BioScience LifeSciences bring you the innovative mycoplasma detection and eradication range from InvivoGen

Plasmocin

Plasmocin contains two bactericidal components strongly active against mycoplasma and related cell wall-less bacteria. It can be used to both treat and prevent mycoplasma contamination in cell cultures.

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Plasmotest

Plasmotest from is a rapid and simple cell based assay for detecting mycoplasma in cell culture. It is a cell-based colorimetric assay that exploits the ability of Toll-like receptor 2 to recognize mycoplasmas and to induce a signaling cascade leading to the activation of NF-kappaB and other transcription factors. In the presence of mycoplasmas, TLR2 expressed on the surface of HEK-Blue-2 cells activates these transcription factors which in turn induce the secretion of sAP (secreted alkaline phosphatase), a reporter protein easily detectable by the purple/blue coloration of the HEK-Blue Detection medium.

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