NLRs
NLRs (also known as CATERPILLERs) constitute a recently
identified family of intracellular PRRs, which contains more than
20 members in mammals. Although the ligands and functions of many
of these receptors are not known, their primary role is to
recognize cytoplasmic PAMPs and/or endogenous danger signal,
inducing immune responses. NLRs have been grouped into several
subfamilies on the basis of their effector domains: NODs, NALPs,
CIITA, IPAF, and NAIPs.
NLR & NLR-Related Genes
InvivoGen offers a large collection of human
and mouse genes involved in the NLR pathway:
• NLR genes • Signaling genes • Signaling inhibitors •
Transcription factors
The entire open reading frames (ORFs) of these genes are
provided in an expression plasmid and are fully sequenced.
NOD Reporter Cell Lines
293/NOD clones are transfected HEK293 cells that express stably
the NOD1 or NOD2 genes (human or murine).
NEW HEK-Blue™ NOD cells are engineered cell lines designed to
screen and validate NOD agonists or antagonists. They express an
NF-κB-inducible SEAP reporter gene.
NOD Ligands
NOD ligands is an expanding collection of molecules that
activate the NOD1/2 pathway. All ligands are tested for activity
and are endotoxin-free.
NLR Inhibition
InvivoGen provides short hairpin RNAs (shRNAs) that silence
specifically a selection of NLRs: IPAF, NALP1/2/3, NOD1/2.
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