InvivoGen offers a large selection of human and mouse genes
involved in the TLR pathways.
Toll-Like Receptors interact with co-receptor molecules to
recognize specific molecular patterns associated with microbial
Upon recognition, they induce distinct cellular responses that
involve different adaptor proteins which in turn will activate a
cascade of signaling genes leading to the production of
TLR and TLR-related genes are provided either native, cloned
from the ATG to the Stop codon, or modified by addition of a tag
and/or deletion to generate dominant negative variants.
• Toll-like receptor genes
• TLR co-receptor genes
• TLR adaptor genes
• TLR regulator genes
• Signaling genes
• Signaling inhibitors
• Transcription factors
• RLR genes
• NLR genes
• CLR, PGRP & Related genes
Native TLR and TLR-related genes are provided in the pUNO
plasmid that can be amplified in E.coli and stably transfected in
mammalian cells using blasticidin.
• HA-tagged genes
HA-tagged genes are provided in the pUNO-HA plasmid, selectable
• Dominant negative (DN) variants
Dominant negative variants are provided in either in the
pZERO-TLR or pDeNy plasmids selectable with puromycin or Zeocin™
• HA-tagged DN genes
HA-tagged dominant negative genes are provided in the
pZERO-TLR-HA plasmid selectable with puromycin.
• TLR-GFP fusion genes
TLR-GFP fusion genes are provided in the pUNO-TLR-GFP plasmid
selectable with blasticidin.